Mato J, Alvarez L, Ortiz P, Pajares MA (1997) S-adenosylmethionine synthesis: molecular

mechanisms and clinical implications. Pharma Ther 73(3):265280. https://doi.org/10.1016/

S0163-7258(96)00197-0

Mato JM, Corrales FJ, Lu SC, Avila MA (2002) S-adenosylmethionine: a control switch that

regulates liver function. FASEB J 16(1):1526. https://doi.org/10.1096/fj.01-0401rev

McGill MR, Yan HM, Ramachandran A, Murray GJ, Rollins DE, Jaeschke H (2011) HepaRG cells:

a human model to study mechanisms of acetaminophen hepatotoxicity. Hepatology 53(3):

974982. https://doi.org/10.1002/hep.24132

McGill MR, Lebofsky M, Norris HRK, Slawson MH, Bajt ML, Xie Y, Jaeschke H (2013) Plasma

and liver acetaminophen-protein adduct levels in mice after acetaminophen treatment: dose

response, mechanisms, and clinical implications. Toxicol Appl Pharmacol 269(3):240249.

https://doi.org/10.1016/j.taap.2013.03.026

Miller MT, Strömland K (1999) Teratogen update: thalidomide: a review, with a focus on ocular

ndings and new potential uses. Teratology 60(5):306321. https://doi.org/10.1002/(SICI)

1096-9926(199911)60:5

Miltonprabu S, Manoharan V (2016) Hepatoprotective effect of grape seed proanthocyanidins on

cadmium-induced hepatic injury in rats: possible involvement of mitochondrial dysfunction,

inammation and apoptosis. Toxicol Rep 3:6377. https://doi.org/10.1016/j.toxrep.2015.

11.010

Mladwenovic KG, Muruzovic MZ, Stefanovic OD, Vasic SM, Comic L (2016) Antimicrobial,

antioxidant and antibiolm activity of extracts of Melilotus ofcinalis (L) pall. J Anim Plant Sci

26(5):14361444

Mohideen S, Ilavarasan R, Sasikala E, Kumaran RT (2003) Hepatoprotective activity of Nigella

sativa Linn. Indian J Pharm Sci 65(5):550

Molina-Montenegro MA, Atala C, Gianoli E (2010) Phenotypic plasticity and performance of

Taraxacum ofcinale (dandelion) in habitats of contrasting environmental heterogeneity. Biol

Invasions 12(7):22772284

Monali P, Ramtej V (2014) Hepatoprotective activity of Boerhavia diffusa extract. Int J Pharm Clin

Res 6(3):233240

Moore KL, Dalley AF (2006) Clinically oriented anatomy, 5th edn. Lippincott Williams and

Wilkins, Philadelphia, p 1209

Moreira AL, Sampaio EP, Zmuidzinas A, Frindt P, Smith KA, Kaplan G (1993) Thalidomide exerts

its inhibitory action on tumor necrosis factor alpha by enhancing mRNA degradation. J Exp

Med 177(6):16751680. https://doi.org/10.1084/jem.177.6.1675

Mroueh M, Daher C, El Sibai M, Tenkerian C (2011) Antioxidant and hepatoprotective activity of

Tragopogon porrifolius methanolic extract. Planta Med 77(12):PF72. https://doi.org/10.1055/s-

0031-1282460

Muriel P (1993) S-adenosyl-L-methionine prevents and reverses erythrocyte membrane alterations

in cirrhosis. J Appl Toxicol 13(3):179182. https://doi.org/10.1002/jat.2550130307

Muriel P (1995) Interferon-α preserves erythrocyte and hepatocyte atpase activities from liver

damage induced by prolonged bile duct ligation in the rat. J Appl Toxicol 15(6):449453.

https://doi.org/10.1002/jat.2550150606

Muriel P (2000) Regulation of nitric oxide synthesis in the liver. J Appl Toxicol 20(3):189195.

https://doi.org/10.1002/(SICI)1099-1263(200005/06)20

Muriel P (2006) Role of nitric oxide in liver disorders. In: Ali S, Friedman SL, Mann DA (eds) Liver

diseases: biochemical mechanisms and new therapeutic insights. Science Publishers, Eneld

(NH), pp 115131

Muriel P (2007) In: Sahu S (ed) Cytokines in liver diseases in hepatotoxicity: from genomics to

in vitro and in vivo models. John Wiley & Sons, Chichester

Muriel P, Mourelle M (1992) Characterization of membrane fraction lipid composition and function

of cirrhotic rat liver: role of S-adenosyl-l-methionine. J Hepatol 14(1):1621. https://doi.org/10.

1016/0168-8278(92)90125-9

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